α-Conotoxin AuIB

CAS No. 216299-21-7

α-Conotoxin AuIB ( )

Catalog No. M30725 CAS No. 216299-21-7

Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    α-Conotoxin AuIB
  • Note
    Research use only, not for human use.
  • Brief Description
    Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.
  • Description
    Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.
  • Synonyms
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    216299-21-7
  • Formula Weight
    1572.8
  • Molecular Formula
    C65H89N17O21S4
  • Purity
    >98% (HPLC)
  • Solubility
    water:5 mg/mL
  • SMILES
    [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)[C@@H](C)O)C(N)=O)NC1=O
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release. J.Neurosci. 18 8571 PMID:
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